Introduction hydroxypropyl methylcellulose is an odorless and tasteless, white to. To produce methylcellulose products, cellulose fibers, mostly from wood pulp, are heated in a caustic solution and then treated with methyl chloride, yielding the methyl ether of cellulose. Hydroxypropyl cellulose ethers which have a methoxyl substitution of from 21% to 35% and a hydroxypropoxyl substitution of from 14% to 35% and which have a viscosity of at least about 50 mpas as a 2 weight percent aqueous solution are useful as thickening agents for organic liquids, optionally mixed with water. Thermal characteristics of hydroxypropyl methyl cellulose. Original article preparation and characterization of crosslinked acrylic acidhydroxypropyl methyl cellulose hydrogels for drug delivery nazar muhammad ranjha 1 and umbreen fatima qureshi2 1faculty of pharmacy, b. Hydroxypropyl methyl cellulose, viscosity 4060 cp, 2 % in h 2 o20 clit. Hydroxypropyl methylcellulose in the construction building. Remove person to fresh air and get medical attention skin contact. Methylcellulose, a cellulose derivative with original. Pelagia research library hydroxypropyl methylcellulose in. Redox is a leading distributor of chemicals and ingredients, active in more than 1,000 specialty and commercial products. The substance identity section is calculated from substance identification information from all echa databases.
Thermal characteristics of hydroxypropyl methyl cellulose article in journal of loss prevention in the process industries 222. Hydroxy propyl methyl cellulose, drug delivery, variants, recent developments. A series of amphiphilic diblock copolymers with different hydrophilic and hydrophobic block lengths were synthesized by reductive amination of hydroxypropyl methyl cellulose hpmc and endfunctionalized poly. Cellulose ether, thermoresponsive polymer, introduction hydrogels can swell in the presence of water or physiological fluids. Hydroxypropyl methyl cellulose chemical structural formula. Definition hypromellose is a methyl and hydroxypropyl mixed etherassay of cellulose. Hypromellose, short for hydroxypropyl methylcellulose hpmc, is a semisynthetic, inert, viscoelastic polymer used as eye drops, as well as an excipient and controlleddelivery component in oral medicaments, found in a variety of commercial products.
The nosb approved powdered cellulose, a less processed material usually derived from wood pulp fiber, for 9 use as a filtering aid and anticaking agent in october of 2001. Application of hydroxypropyl methylcellulose in food and cosmetic industries. It is prepared by reacting alkali treated cellulose first with methyl chloride to introduce methoxy groups and then with propylene oxide to introduce propylene glycol ether groups. The preparation technology comprises the following steps of.
Hydroxypropylmethyl cellulose average mn 10,000 sigma. Methocel products have also been reported for the following inventories. The mc is then also reacted with 66 propylene oxide to form hpmc. Definition hydroxypropylmethyl cellulose is a methyl cellulose modified by treatment with alkali and propylene oxide by which a small number of 2hydroxypropyl groups are attached through ether links to the anhydroglucose units of the cellulose. American polymer standards corporation safety data sheet. Safety of a change in specifications for the food additive hydroxypropyl methyl cellulose e 464 view page or view pdf reevaluation of celluloses e 460i, e 460ii, e 461, e 462, e 463, e 464, e 465, e 466, e 468 and e 469 as food additives. Hydroxypropyl methylcellulose hpmc prevents the whiten degeneration resulting from the decomposition of citrus glycosides during storage and thus achieves preservation effects. Hpmc is hydrophilic water soluble, a biodegradable, and biocompatible polymer having a wide range of applications in drug delivery, dyes and paints, cosmetics, adhesives, coatings. Ethyl cellulose ec is a nontoxic, stable, compressible, inert, hydrophobic polymer that has been widely used to prepare pharmaceutical dosage forms. You will need to talk about the benefits and risks of using hydroxypropyl methylcellulose while you are pregnant.
Hydroxypropyl methylcellulose hpmc belongs to the group of cellulose ethers in which hydroxyl groups have been substituted with one or more of the three hydroxyl groups present in the cellulose ring fig. Hpc is an et her o f cellulose in which some o f t he hydroxyl groups in the repeating g lucose units have been hydroxypropylated for ming och 2 ch oh ch3. We search the world and bring only the highest quality materials to customers throughout australia, new zealand, malaysia and the united states of america. Us4614545a hydroxypropyl methyl cellulose thickening. Nh2pcl was synthesized by ringopening polymerization of. Find patient medical information for hydroxypropyl cellulose on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Application of hydroxypropyl methylcellulose in food and.
Optimization of quality properties of glutenfree bread by. Portions of this monograph that are national usp text, and coated with a 3m layer of phase g1. Properties of hpmc hydroxypropyl methylcellulose hydroxypropyl methylcellulose is a nonionic cellulose ether, in the appearance of white powder, odorless and tasteless. This information from lexicomp explains what you need to know about this medication, including what its used for, how to take it, its side effects, and when to call your healthcare provider.
Cas is 9004675 for methylcellulose and 9904653 for hydroxypropyl methylcellulose. General properties of methocel cellulose ethers general properties common to the whole family of methocel cellulose ether products are listed below. Application of hydroxypropyl methylcellulose in the. Methocel products, methylcellulose and hydroxypropyl methylcellulose, comply with all applicable rules and orders under toxic substances control act pl94469. The getty conservation institute the getty conservation institute gci, an operating program of the j. Hydroxypropyl cellulose an overview sciencedirect topics.
Methyl cellulose mc, hydroxypropyl cellulose hpc, hydroxypropylmethyl cellulose hpmc, ethylcellulose ec, sodium carboxymethylcellulose nacmc, and carboxymethyl cellulose cmc are cellulose derivatives which are used in hydrogel preparation through physical and chemical crosslinking. Hydroxypropyl methyl cellulose also carries code e464 in the european union, making it a known and listed food additive. Hydroxy propyl methyl cellulose hpmc, a cellulose derivative used in pharmaceutical industries, was employed as the basic formulation component to coat fresh blueberries. Safety assessment of hydroxypropyl methylcellulose as a food. Methocel is an excellent rheology modifier, binder, film former, and waterretention. It is requested that the limit of the sum of the two isomers 1chloro2propanol and 2chloro1propanol of propylene chlorohydrin pch in hpmc be raised from 0. Common name hydroxypropyl methylcellulose chemical name cellulose, 2 hydroxypropyl methyl ether chemical structure cas number 9004653 proportion range more than 95% 4. Methylcellulose mc is one of the most important commercial cellulose ethers and it has been used in many industrial applications 2,3. Hydroxypropyl methyl cellulose hpmc, is nonionic cellulose ether, and a modified cellulose ether derivatives polymer that is offwhite in color and considered safe for human consumption. Hydroxy propyl methyl cellulose material safety data. Chemical name cellulose, 2 hydroxypropyl methyl ether chemical structure cas number 9004653 proportion range more than 95% 4. Hypromellose, short for hydroxypropyl methylcellulose hpmc, is a semisynthetic, inert, viscoelastic polymer used as eye drops, as well as an excipient and controlleddelivery component in oral medicaments, found in a variety of commercial products as a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin.
Difference between methyl cellulose mc and hydroxypropyl methyl cellulose hpmc 1. It is soluble in water, most polar organic solvents, and the appropriate proportion of ethanolwater, propanol water and. Hydroxypropyl methyl cellulose is easily soluble in cold water but difficult to be soluble in hot water. Find overview, chemical composition, chemistry information, uses and benefits details of hydroxypropyl cellulose active pharmaceutical ingredient in pdf document on. Should you have any questions about the hydroxypropyl cellulose monograph, please contact dr. Physical properties of tablet hpmc is compatible with a variety of ingredients that are used in the preparation of tablets.
Safety of a change in specifications for the food additive. It is used as an excipient, and topical ophthalmic protectant and lubricant. Hydroxypropyl methylcellulose ingredient for cosmetics formulations find latest products launched and their applications in relevant industry news and technical articles. Find patient medical information for hydroxypropyl cellulose ophthalmic eye on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Jun 27, 2018 hydroxypropyl methylcellulose is used for artificial tears for dry eyes, dry eyes, eye disorders and other conditions. Use dry chemical powder, water spray fog, foam or co2 unsuitable extinguishing media.
Hydroxypropyl methylcellulose drug information, professional. It must be treated carefully, however, as it does react strongly if exposed to oxidizing agents. Hydroxypropyl methylcellulose helps to increase the dispersion of cementsand, greatly improve the plasticity of mortar and waterholding capacity, prevent cracks and enhance the strength of cement. Wash the contaminated area with soap and water sufficiently. American polymer standards corporation safety data sheet page 2 of 5 hydroxypropyl methylcellulose section 5.
Hold time initial tempera final at final hydroxypropyl cellulose is. Cn102807624a preparation technology of hydroxypropyl. Chemistry of methocel cellulose ethers a technical. Add 10 ml of chromium trioxide solution 30 g in 70 ml. Methocel cellulose ethers include methylcellulose mc or hydroxypropyl methylcellulose hpmc polymers with solubilities ranging from watersoluble to organosoluble. Evaluation of cellulose ethers for conservation 1990. If hydroxypropyl methylcellulose is put in the mouth or swallowed, call a doctor or poison control center right away. Hydroxypropyl methylcellulose is produced by treating heated cellulose fibers with a caustic solution which in turn is reacted with methyl chloride and propylene oxide yielding the propyl methyl ether of cellulose. There are two grade in this product, industrial grade and pharm grade. Hydroxypropyl methylcellulose cosmetic ingredient inci. Firefighting measures suitable extinguishing media.
Some of these products are not for use if you are wearing contact lenses. It must be treated carefully, however, as it does react strongly if. Use dry chemical powder, water spray fog, foam or co2. Hpc is an ether of cellulose in which some of the hydroxyl groups in the repeating glucose units have been hydroxypropylated forming och 2 ch ohch 3 groups. Thermal conductivity or hydrogen flame loss on drying. The fibrous reaction product is filtered, dried, and ground into a fine, uniform powder. Ac244020000, ac244020010, ac244020050, ac24402, ac244022500 synonyms.
Hpmc has not been evaluated in any standard reproduction test. The invention relates to a preparation technology of hydroxypropyl methylcellulose ether hpmc, belonging to the field of the fine chemical industry. For each of the quality properties measured, a twofactor interaction model was. The top countries of suppliers are india, china, from which the percentage of hydroxypropyl methylcellulose supply is 1%, 99% respectively. Powdered cellulose is also used as a thickening agent.
Hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, hydroxypropyl methylcellulose, and cellulose gum are modified cellulose polymers that are used in cosmetic products at concentrations up to 10%. Hydroxypropyl methylcellulose, k100m usp grade supplier. First aid measures description of firstaid measures inhalation. Hydroxypropyl methylcellulose is a white, odourless, tasteless powder made chemically through the modification of cellulose. Mar, 2018 introduce of hpmc hydroxypropyl methylcellulose. Wash the contaminated area with soap and water sufficiently if irritation develops get medical attention. Mc is the simplest cellulose derivative, where methyl groups ch3 substitute the hydroxyls at c2, c3 andor c6 positions of anhydrodglucose units figure 1. A wide variety of hydroxypropyl methylcellulose options are available to you, there are 758 suppliers who sells hydroxypropyl methylcellulose on, mainly located in asia. It is odorless, tasteless, and in the shape of white powder. Hydroxypropyl methylcelluloseintroductions cellulose ether. Process8,9 methocel cellulose ethers are available in two basic types. Hydroxypropyl cellulose the upper phase as the sample solution.
Hydroxypropylmethyl cellulose viscosity 2,6005,600 cp, 2 % in h2o20 clit. Hpmc is a semisynthetic compound that is nontoxic to humans. Hydroxypropyl cellulose definition of hydroxypropyl. Tell your doctor if you are pregnant or plan on getting pregnant. Clear micellar conditioner iecic compliant by colonial chemical this clear micellar conditioner iecic compliant features poly suga quat l1010p and cola lipid c in a siliconefree, clear conditioner.
One reagent lane fair lawn, nj 07410 for information in north america, call. However, hydroxypropyl cellulose a similar cellulose derivative has been tested in both rats and rabbits. The substance identifiers displayed in the infocard are the best available substance name, ec number, cas number andor the molecular and structural formulas. Hydroxypropyl cellulose hpc is a derivative of cellulose with both water solubility and organic solubility. One study in rats indicated there was an increase in fetal resorptions, gross and skeletal malformations after a 1 and 4% hpmc i. Safety assessment of hydroxypropyl methylcellulose as a. It is used in the food industry as a multipurpose food ingredient. Deterministic approach assuming 100% probability of presence of methyl cellulose in all food groups and a fixed maximum concentration highest. The article in commerce may be further specified by viscosity. Hydroxypropyl methylcellulose hpmc is mixed alkyl hydroalkyl cellulose ether containing methoxy and hydroxypropyl groups. Tablet enteric coating agent, filmcoating, and as a matrix for use in extendedrelease tablet formulations. Procedure transfer about 65 mg of hydroxypropyl cellulose, previously dried at 105 for 1 hour and accurately weighed, into the reaction flask.
Cellulose and its derivatives use in the pharmaceutical. Hydroxypropylmethyl cellulose viscosity 2,6005,600 cp, 2 %. The cellulose derivatives pass essentially unchanged through the gastrointestinal tract following oral administration. Apr 05, 2019 hydroxypropyl methylcellulose phthalate. Synthesis and selfassembly of hydroxypropyl methyl.
It helps in maintaining the shelf life of the product because by the virtue of its property it prevents microbial. Hydroxypropylmethylcellulose an overview sciencedirect. Hydroxypropyl methylcellulose is a nonpyrogenic viscoelastic solution that occupies space and protects tissue. Hypromellose phthalate hydroxypropyl methylcellulose phthalate, or hpmcp is a phthalic acid ester of hydroxypropyl methylcellulose. Comparison of the efficacy of carboxymethylcellulose 0. Apr 30, 2020 hydroxypropyl methyl cellulose also carries code e464 in the european union, making it a known and listed food additive. Use hydroxypropyl methylcellulose as ordered by your doctor. Common name hydroxypropyl methylcellulose synonyms hydroxypropyl methyl cellulose cas number 9004653 section 4. Hydroxy propyl methyl cellulose mhe261 hydroxypropyl methyl cellulose hpmc is a nonionic cellulose ether made by a series of either based on natural macromolecule cellulose as raw material.
Characteristics of hydroxy propyl methyl cellulose hpmc. Industrial grade main used in building industry, like retaining agent, retarder, adhesives, water preserving agent, filmforming agent, also used in ceramic industry as adhesives. Cellulose and its derivatives use in the pharmaceutical compounding practice 145 in compounded medicines, powdered cellulose and microcrystalline cellulose are used as an adsorbent, a suspending agent, a capsule diluent 530% and 2090%, respectively. Addition of carrageenan, plasticizer and carnauba wax emulsion add value to film structure and functionality. Paul getty trust, was created in 1982 to enhance the. The production of hydroxypropyl methylcellulose products is similar, except propylene oxide is used in addition to methyl chloride to obtain hydroxypropyl substitution on some of the anhydroglucose units. Stage 6 harmonization 2 hypromellose official december 1, 2016 mode.